科普專欄–薯不揀單 - 三十秒科學–癌細胞裡頭的油脂粒

前列腺癌與正常前列腺細胞的其中一道不同之處，就是前列腺癌細胞裡頭含有豐盛的油脂粒(Lipid Droplet)。543Please respect copyright.ＰＥＮＡＮＡQXVfb1lYOQ
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油脂粒為細胞儲存脂肪的一道地方，在不少癌症例如乳癌、腸癌及腦癌也能找得到數量充盛的油脂粒。543Please respect copyright.ＰＥＮＡＮＡMuVXeDeaAM
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（圖2）前列腺癌細胞油脂粒的主要成份，是名為Cholesteryl ester (CE)的物質，543Please respect copyright.ＰＥＮＡＮＡWri0g8ccLQ
簡單來說可以看成為脂肪酸與膽固醇結合在一起的物質。543Please respect copyright.ＰＥＮＡＮＡJmFjORglf8
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（圖3）CE，亦即是前列腺癌細胞油脂粒的主要成份，是依靠細胞裡頭一隻名為ACAT的蛋白酶製作而成。543Please respect copyright.ＰＥＮＡＮＡ40tJAjtzqx
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利用抑壓ACAT的藥物不但之能夠將老鼠的前列腺腫瘤縮小，更對老鼠身體的其他器官及細胞並無做成任何大的影響。543Please respect copyright.ＰＥＮＡＮＡuvytdQTC3V
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某部份的前列腺癌細胞可依靠抑壓雄激素來阻止其生長，但此方法並非絕對有效，某部份的前列腺癌細胞並不依賴雄激素亦能快速生長及轉移到骨頭等各身體部位。543Please respect copyright.ＰＥＮＡＮＡurixL2IT7h
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在這種情況下，針對前列腺癌細胞的油脂新陳代謝來抑壓其生長，未嘗不是一道可行的方向。543Please respect copyright.ＰＥＮＡＮＡtaK1RiW2JA
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。543Please respect copyright.ＰＥＮＡＮＡ7rCH56Irli
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc543Please respect copyright.ＰＥＮＡＮＡIdD7UrgmSW
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。543Please respect copyright.ＰＥＮＡＮＡYGi73JvyQb
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Link:543Please respect copyright.ＰＥＮＡＮＡNIsOnCQAsT
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio543Please respect copyright.ＰＥＮＡＮＡ5p1c4jjdkM
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。543Please respect copyright.ＰＥＮＡＮＡfnqKoE1JG3
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Ref1:https://pubmed.ncbi.nlm.nih.gov/24606897/543Please respect copyright.ＰＥＮＡＮＡnk54RX9aa1

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