科普專欄–薯不揀單 - 三十秒科學–癌細胞轉移後所產生的變化

癌細胞的新陳代謝與普通細胞有著顯著的分別，原因是癌細胞需要截然不同的新陳代謝來滿足生長的需要。707Please respect copyright.ＰＥＮＡＮＡGb2jcJ9pRS
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但是，當癌細胞從原有位置轉移到另一位置後，其新陳代謝有會否有所轉變呢?707Please respect copyright.ＰＥＮＡＮＡHH5ATKQABk
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（圖2）mTORC1是其中一隻掌管細胞生長的蛋白質，而有研究(Ref1)指出，從乳癌轉移到肺部的癌細胞，其mTORC1所帶來的效果更為強大，能令癌細胞生長得更快。707Please respect copyright.ＰＥＮＡＮＡ5KAmg7mcyq
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（圖3）科學家發現，肺部含有充足的Pyruvate代謝物，而利用藥物阻擋「乳癌轉移過來的肺癌」吸收Pyruvate的話，便能減低mTORC1的功效。707Please respect copyright.ＰＥＮＡＮＡmXdwaqkcLR
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但奇怪的是，用藥物阻擋原發腫瘤乳癌吸收Pyruvate的話，mTORC1的功效並不會有所減低，腫瘤生長的速度並無任何特別變化。707Please respect copyright.ＰＥＮＡＮＡ7AmlYVl5KO
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這顯示出，癌細胞從原有地方轉移到另一位置後，其新陳代謝亦有著顯著的變化。707Please respect copyright.ＰＥＮＡＮＡGTrJrEISPT
這有可能是因為第二處位置的生長環境有所不同，故此癌細胞需要調節其新陳代謝來適應新環境。707Please respect copyright.ＰＥＮＡＮＡV7YQltf9Zh
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在乳癌轉移到肺部的癌細胞，我們可透過針對Pyruvate的吸收來減慢他們的生長，但這是否只適用於從其他位置轉移到肺部的癌細胞，以及乳癌轉移到其他位置的癌細胞，那還需要進一步的研究確實。707Please respect copyright.ＰＥＮＡＮＡaX8V425CwW
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。707Please respect copyright.ＰＥＮＡＮＡHhFdMF8FKw
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc707Please respect copyright.ＰＥＮＡＮＡ4SXM6pJvEP
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。707Please respect copyright.ＰＥＮＡＮＡhsyGSvtdRb
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Link:707Please respect copyright.ＰＥＮＡＮＡmalNXAHPKM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio707Please respect copyright.ＰＥＮＡＮＡIFOj2Q5X4W
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。707Please respect copyright.ＰＥＮＡＮＡueaCgckN7t
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Ref1:https://www.sciencedirect.com/science/article/pii/S1097276520308273707Please respect copyright.ＰＥＮＡＮＡUpdmOGdzus

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