科普專欄–薯不揀單 - 三十秒科學–控制肌肉重量的一隻蛋白酶

肌肉大概佔據身體重量的40%。537Please respect copyright.ＰＥＮＡＮＡDrczbmRp9W
537Please respect copyright.ＰＥＮＡＮＡK83Nc8n1bc
537Please respect copyright.ＰＥＮＡＮＡf4rqRuf87r
踏入50歲後，平均每10年就會有15-30%的肌肉流失。537Please respect copyright.ＰＥＮＡＮＡONve84KrUx
537Please respect copyright.ＰＥＮＡＮＡDUGkhkHETY
（圖2）研究(Ref1)顯示老人家的肌肉裡頭，一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。537Please respect copyright.ＰＥＮＡＮＡ2urm7CXB5u
537Please respect copyright.ＰＥＮＡＮＡutX5w62EHM
537Please respect copyright.ＰＥＮＡＮＡKQD1cn70OC
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。537Please respect copyright.ＰＥＮＡＮＡYilORVXQY8
537Please respect copyright.ＰＥＮＡＮＡgHdLTgdhxr
(圖3）而人類老化所出現的現象，老鼠亦能同樣發現得到。537Please respect copyright.ＰＥＮＡＮＡCS0vDFv4zG
除肌肉外，年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。537Please respect copyright.ＰＥＮＡＮＡPJOpykq14V
537Please respect copyright.ＰＥＮＡＮＡlovZMkadwb
537Please respect copyright.ＰＥＮＡＮＡ8v0aQclLsT
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話，肌肉重量亦會有所提升。537Please respect copyright.ＰＥＮＡＮＡDhYi9kXHxx
537Please respect copyright.ＰＥＮＡＮＡEXZJ1tQXoa
相反，若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話，肌肉重量亦會有所下降。537Please respect copyright.ＰＥＮＡＮＡNsz07JoaHx
537Please respect copyright.ＰＥＮＡＮＡgnoqL0H5AH
這道研究展示出，只需對一隻蛋白酶作出針對性的抑制，便能夠達到控制肌肉重量及結構的奇效。537Please respect copyright.ＰＥＮＡＮＡZtM4Pt2aCD
537Please respect copyright.ＰＥＮＡＮＡfNeoX0ZYRD
現時已有藥物可抑制15-PGDH，但對於人類肌肉影響的臨床研究則欠奉。537Please respect copyright.ＰＥＮＡＮＡ2ZcAiGEVyV
537Please respect copyright.ＰＥＮＡＮＡCi2h2ouWBU
只不過的是，現今均普遍認為增加體內細胞NAD數量的話，便可舒緩甚至是扭轉細胞的老化現象。然而，15-PGDH卻需要NAD才能正常運作，這一方面所出現的矛盾則未能解釋得到。537Please respect copyright.ＰＥＮＡＮＡCjAiXXRWhN
537Please respect copyright.ＰＥＮＡＮＡ1qUtXJvjsy
537Please respect copyright.ＰＥＮＡＮＡfO55s8hWRD
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。537Please respect copyright.ＰＥＮＡＮＡf00GQ3ugJi
537Please respect copyright.ＰＥＮＡＮＡPPuz6knAPy
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc537Please respect copyright.ＰＥＮＡＮＡkZYGknlS4d
537Please respect copyright.ＰＥＮＡＮＡCy2IhEDUJF
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。537Please respect copyright.ＰＥＮＡＮＡoPbbsAKYQQ
537Please respect copyright.ＰＥＮＡＮＡ0nOUyvJWc5
Link:537Please respect copyright.ＰＥＮＡＮＡs5Via6w4GM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio537Please respect copyright.ＰＥＮＡＮＡQTdYjHli0l
537Please respect copyright.ＰＥＮＡＮＡKyiDvJkCtn
537Please respect copyright.ＰＥＮＡＮＡHEOSCLKbmr
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。537Please respect copyright.ＰＥＮＡＮＡzZLl56ZLk6
537Please respect copyright.ＰＥＮＡＮＡROKIEclMvX
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059537Please respect copyright.ＰＥＮＡＮＡqJ2hp9dQUA

ns216.73.216.190da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章