肌肉大概佔據身體重量的40%。495Please respect copyright.PENANAuE69O91M0M495Please respect copyright.PENANADmq8dF8tUG
495Please respect copyright.PENANAB0215zc3ff
踏入50歲後,平均每10年就會有15-30%的肌肉流失。495Please respect copyright.PENANAY1joD4zGXI
495Please respect copyright.PENANAGdxQfDyJas
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。495Please respect copyright.PENANAXR431HahBP495Please respect copyright.PENANAmyt2ODu7N2
495Please respect copyright.PENANAOTvzl1luVU
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。495Please respect copyright.PENANArGVjUYGPuh
495Please respect copyright.PENANAQHIlSoF7Yr
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。495Please respect copyright.PENANAKYz7iMiFQD
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。495Please respect copyright.PENANAQWhkcJdvvf495Please respect copyright.PENANAIeHRRaXCvb
495Please respect copyright.PENANAtbfkUYZr6g
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。495Please respect copyright.PENANA6l856Nm9CP
495Please respect copyright.PENANA3zHQEYv9yx
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。495Please respect copyright.PENANALjVViYARMH
495Please respect copyright.PENANAJqB2SH9aPN
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。495Please respect copyright.PENANAYg4FRYOvWq
495Please respect copyright.PENANAnLy3O1avZy
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。495Please respect copyright.PENANAX34JypxCPV
495Please respect copyright.PENANAb22qU9F7du
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。495Please respect copyright.PENANAHs1Sv329WV
495Please respect copyright.PENANAnQRHDqCsOW
495Please respect copyright.PENANAD1lPzMkYla
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。495Please respect copyright.PENANA11rmgK9xJl
495Please respect copyright.PENANAOXkDTAxwUB
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc495Please respect copyright.PENANAW8DAATarlc
495Please respect copyright.PENANAfdrH5EkyS1
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。495Please respect copyright.PENANAp5FKjSIel7
495Please respect copyright.PENANAxmXMrrGyHn
Link:495Please respect copyright.PENANAyXJrXVRAKC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio495Please respect copyright.PENANAsw0pUp4y4P
495Please respect copyright.PENANA486zIRwYLT
495Please respect copyright.PENANAleMTVlHNn5
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。495Please respect copyright.PENANA8afylnOA46
495Please respect copyright.PENANAotaF2sr7y2
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059495Please respect copyright.PENANAqxxJVwU5pH
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #146
三十秒科學–控制肌肉重量的一隻蛋白酶
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