在應對武肺的方針上,中國現時共有兩款滅活疫苗處於臨床研究Phase3的過程。1162Please respect copyright.PENANALB421l749U1162Please respect copyright.PENANAeB1UcrS1mt
1162Please respect copyright.PENANAFJXsUSrp9Q
兩款設計理念相同的疫苗分別為香港人相對較為認識的科興(Sinovac),以及國營機構(Sinopharm/CNBG)。1162Please respect copyright.PENANA8f3B8obNtT
1162Please respect copyright.PENANA6EpkgczvBw
只不過,既然設計理念相同,那麼兩者的分別究竟何在呢?1162Please respect copyright.PENANAZqT0RLlkSx
1162Please respect copyright.PENANAzH8zrw636n
1162Please respect copyright.PENANAheTmm1N0QL
(圖2)在深入兩者分別前,我們需要理解一下滅活疫苗的製造方式。1162Please respect copyright.PENANAXXBbzrIVAH1162Please respect copyright.PENANACSZVTnYKEQ
1162Please respect copyright.PENANAV9FWBAObbo
首先,醫生或科學家會從一名進入深切治療部的中國病患肺部體液中抽取病毒,經過數輪實驗室細胞的培植,最後加入化學物消減病毒的感染力以及多重過濾,最終取得弱化的武肺病毒作疫苗的原材料。1162Please respect copyright.PENANA3owsoIGE2h
1162Please respect copyright.PENANAmRLAMl1MZT
從病人體液中抽取病毒後,病毒便可經由實驗室細胞無限量地培植,不需再向病人作任何的抽取動作。1162Please respect copyright.PENANA6RFdT4pCYz
1162Please respect copyright.PENANAebydumq5Jn
(圖3)根據現有文獻(Ref1及Ref2),科興疫苗的病毒原材料為CN2 strain,而國營疫苗的病毒原材料為WIV04 strain;1162Please respect copyright.PENANADD2QjFASqr
為方便有興趣的讀者,兩者排組的超連結已列在文末。1162Please respect copyright.PENANAEUf0FOv5Ka1162Please respect copyright.PENANA6nNlNpd4Sq
1162Please respect copyright.PENANApzcG0X3F5l
比較兩款疫苗的病毒原材料的氨基酸排組,兩者在學界所認定的區域中接近是一模一樣,唯一的方別就處於Orf8區域上,箇中有著一顆氨基酸的差別不同。1162Please respect copyright.PENANAt7VVjvw2XV
1162Please respect copyright.PENANAJkhj26WT87
(圖4)Orf8的84號位置氨基酸經常被錄得變異,而科興及國營所用的病毒原材料,在該位置的氨基酸並不相同。1162Please respect copyright.PENANAGYcLmg9gE51162Please respect copyright.PENANACLbzbseZMm
1162Please respect copyright.PENANAMFhvMrzZhH
1162Please respect copyright.PENANAGEBI7IlNP5
(圖5)另外,兩款疫苗均用上化學物beta-propiolactone(BPL)消減病毒感染力。籠統來說,BPL能夠與蛋白質產生化學作用,因而能夠對病毒的各種結構作出一定程度的「破壞」。1162Please respect copyright.PENANAFc82WIN0El1162Please respect copyright.PENANAr8fwI4lupT
1162Please respect copyright.PENANAxGyaVbuPhS
這化學物較常用在消毒手術工具等方面,基於這物質揮發性較高,消毒完成後可透過加熱或真空的方式移除化學物。1162Please respect copyright.PENANAZFEtbnrrtu
但基於其致癌的性質,這化學物並不適宜動用在沒有專業工具或設施的日常方面。1162Please respect copyright.PENANApByQcuesV8
1162Please respect copyright.PENANAB0gc1gvVOZ
有趣的是,根據文獻記載,科興疫苗所用的BPL消毒時間為24小時,而國營疫苗所用的BPL消毒時間為48小時。1162Please respect copyright.PENANAHBP2jHYNj4
兩者有所差別的原因暫時不詳,有可能是兩者所用的BPL濃度有所不同,因此所需的消毒時間亦有分別。1162Please respect copyright.PENANAV0ecv5HZAD
1162Please respect copyright.PENANARcFsGeU6CN
有心的讀者可以比對一下兩款疫苗所用的BPL濃度,本人暫時找不到相關資料作出比對。1162Please respect copyright.PENANAYPwQHnC1fH
1162Please respect copyright.PENANAK84IQwAUC8
除病毒原料排組、BPL消毒時間外,兩款疫苗在製作上可能亦有著截然不同的分別,但本人閱覽現知已公開的文獻資料後並找不出適當的資料作對比,非常歡迎有心人提供可作引用的公開資料作補充。1162Please respect copyright.PENANAZUP09OgtZU
1162Please respect copyright.PENANAZUX04Hjpjp
而在物流的處理上,根據新華社報導(Ref5),中國已在公開第三期臨床報告前為四百五十萬人注射國產疫苗,而國營疫苗手頭上暫時共有一千萬枝疫苗,2021年預計能生產一億枝疫苗(Ref6)。1162Please respect copyright.PENANAhm6hovf4Ht
1162Please respect copyright.PENANAcM1y1pDKOC
而讓人振奮的是,中國在12月31日的公開記者會上表示(Ref5),將會免費為所有中國人注射國產疫苗。1162Please respect copyright.PENANA2thThLXDgX
1162Please respect copyright.PENANA6YPjaFVqnr
然而,繼新年賀辭及淘寶上均被遺忘的香港,在法庭上雖已遵照人民日報的領導下將肥佬黎再度囚禁,但亦未能獲得中國的垂青,只能跟巴西及土耳其等國家一樣,獲取購買科興疫苗的權利,而不能得到中國人免費注射國產疫苗的恩賜。1162Please respect copyright.PENANAheXxVMTvyp
1162Please respect copyright.PENANAfumh6znIXy
1162Please respect copyright.PENANAbIAu3P06fI
CN2 strain排組: https://www.ncbi.nlm.nih.gov/nuccore/MT407650.1/ (Sinovac)1162Please respect copyright.PENANAI2p4RlP2fh
WIV04 strain排組:https://www.ncbi.nlm.nih.gov/nuccore/MN996528.1/ (Sinopharm)1162Please respect copyright.PENANAqcSOuWe6SP
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202686/1162Please respect copyright.PENANA4QDWSsSpig
Ref2:https://jamanetwork.com/journals/jama/fullarticle/27696121162Please respect copyright.PENANAIxWYRUpXHw
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577707/1162Please respect copyright.PENANA5e3Vv3BK9L
Ref4:https://science.sciencemag.org/content/370/6522/12631162Please respect copyright.PENANAqL8oFtpicn
Ref5:http://www.xinhuanet.com/english/2020-12/31/c_139632627.htm1162Please respect copyright.PENANA5zxwbF37sA
Ref6:https://www.sciencemag.org/news/2020/12/it-s-crazy-upbeat-covid-19-vaccine-news-china-and-uk-leave-scientists-wanting-more1162Please respect copyright.PENANAhD5FgpcM7y
1162Please respect copyright.PENANAqQer4xnmOJ
1162Please respect copyright.PENANAPua2vzg5p3
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。1162Please respect copyright.PENANAp9u24MNGC5
1162Please respect copyright.PENANAewDHAP59Nu
https://www.instagram.com/potatopigtongue/1162Please respect copyright.PENANAI4lo6fKYIG
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline 資料
-
toc 目錄
-
share 分享
-
format_color_text 介面設置
-
exposure_plus_1 推薦
-
打賞
-
report_problem 檢舉
-
account_circle 登入
X
科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #128
深入淺出–兩款國產滅活疫苗的分別及其反思
喜歡 1
閱讀 1158
書籤 150
campaign
催更 0
打賞

按此加載下一章
X
每次催更後,作者都會收到通知!
smartphone100 → 催更
×
寫下你喜歡這個故事的地方
×
對此喜歡的人