血糖高企是糖尿病其中之一的特徵。492Please respect copyright.ＰＥＮＡＮＡD464vJh1a9
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注射胰島素能加快身體細胞吸取血液糖份的速度，幫助降低血糖濃度，而前提當然是患者的身體細胞依然能對胰島素起上反應。492Please respect copyright.ＰＥＮＡＮＡEOdGjrnHZR
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（圖2）常用的胰島素Glargine接近需要每日注射一次，有不少病人因嫌麻煩或其他原因沒能持之以恆注射，導致沒法完整地完成療程。492Please respect copyright.ＰＥＮＡＮＡY7KgVMJEOx
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現今廠商開發了名為Icodec的胰島素，標榜只需一星期打一次，亦能達致體內胰島素每日平均的濃度與Glargine用家大致相同。492Please respect copyright.ＰＥＮＡＮＡYmZEOp9NEW
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Icodec經過一系列的結構改造，使其能夠與血液含量豐富的白蛋白(Albumin)結合，492Please respect copyright.ＰＥＮＡＮＡ6ByY8zcy2Q
達致在血液中緩慢釋放胰島素到達細胞的效果。492Please respect copyright.ＰＥＮＡＮＡzh3b8PHngH
而且蛋白酶分解它的速度有所被調減，因此可以達致一劑過高濃度，而又能穩定地慢慢以低劑量的方式釋放到細胞裡頭。492Please respect copyright.ＰＥＮＡＮＡk9nyPkoA8D
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（圖3）經過26星期的療程後，需要一日打一次的Glargine(122人)與只需一星期打一次的Icodec(125人)均能降低血糖濃度，而且兩者並無顯著的分別(Ref1)。492Please respect copyright.ＰＥＮＡＮＡ4Ad8mwfOvC
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若能招募更多人士確立其安全性及功效，只需一星期打一次的Icodec將來或許能打入市場，有助便利病人完成整個療程。492Please respect copyright.ＰＥＮＡＮＡwgGfJZWbIs
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但這並不代表Glargine的市場會完全地被取締，當用家需要因每日所需調整胰島素濃度的話，Glargine始終是較佳的選擇。492Please respect copyright.ＰＥＮＡＮＡdihMlUM56c
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。492Please respect copyright.ＰＥＮＡＮＡWHqNL51mjO
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Ref1: https://www.nejm.org/doi/10.1056/NEJMoa20224748964 copyright protection488ＰＥＮＡＮＡiZFwQKiPSv 維尼

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