真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。388Please respect copyright.PENANAKq3Yg5KVgA
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。388Please respect copyright.PENANA0R6XT576la
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1.Azole388Please respect copyright.PENANA0RIxGlSNrw
抑制構成細胞膜的Ergosterol產生388Please respect copyright.PENANAp5s6nqeQP9
2. Polyene388Please respect copyright.PENANAVpoBR370to
消耗細胞膜的Ergosterol388Please respect copyright.PENANAy5hvV3HQE5
3. Echinocandins388Please respect copyright.PENANAS5UWc9Htkw
抑制構成細胞外層的糖分組織產生388Please respect copyright.PENANAx93JlqW9Gx
388Please respect copyright.PENANAg1YEObyzze
388Please respect copyright.PENANAA5FZkDyMEh
(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。388Please respect copyright.PENANA42dtpYbYh5
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388Please respect copyright.PENANAu0VNz5G8UL
它能夠透過血液循環系統走進全身各部位,引發感染。388Please respect copyright.PENANAvcZS585pmm
388Please respect copyright.PENANA9SD4sZd4VN
就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。388Please respect copyright.PENANApksj1sg1sW
388Please respect copyright.PENANArmuGkWI4v7
(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。388Please respect copyright.PENANA8MRg2kkXtQ
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Turbinmicin能有效抑制不同真菌品種,包括Candida auris。388Please respect copyright.PENANAQuXfbIbVqL
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它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。388Please respect copyright.PENANAZd9pRuc4UG
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它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。388Please respect copyright.PENANAi4No0e9ST6
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但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。388Please respect copyright.PENANA0eqi7wvur6
388Please respect copyright.PENANA8lF5QDixFX
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深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。388Please respect copyright.PENANAcQ19SluK6e
388Please respect copyright.PENANAExzwLBZOg7
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。388Please respect copyright.PENANA3m1oGYeQMr
388Please respect copyright.PENANAzr3neWKGZ8
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc388Please respect copyright.PENANAtyPCPYlemb
388Please respect copyright.PENANAJNUHwSwHvl
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。388Please respect copyright.PENANAXP8D5F86ld
388Please respect copyright.PENANAGBscGZeTxA
Link:388Please respect copyright.PENANAT3WOWie0Z9
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio388Please respect copyright.PENANAZmzLYXWyJs
388Please respect copyright.PENANAOBB7G8sefJ
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。388Please respect copyright.PENANAwea9uR2UeS
388Please respect copyright.PENANAxwRpAP4rPp
https://www.instagram.com/potatopigtongue/388Please respect copyright.PENANAocVjEp7vQc
388Please respect copyright.PENANAY4wA82fnmV
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112388Please respect copyright.PENANAzGIo5H6f6r
Ref2:https://science.sciencemag.org/content/370/6519/974388Please respect copyright.PENANA5dAVOvSlcH
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #108
深入淺出–從深海生物中發掘出抗真菌藥物
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