科普專欄–薯不揀單 - 深入淺出–用西醫科學角度審視中藥藥材(1)

中藥與西藥的比拼經常出現，箇中經常出現的論據就是中藥缺乏科學精密驗證，純粹是依靠經驗及神農嘗百草的方式積聚理論。550Please respect copyright.ＰＥＮＡＮＡQFoJ6uutm8
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本篇文章無意將中藥及西藥對衡，而是嘗試以西醫科學角度審視一款中醫藥材，三七。550Please respect copyright.ＰＥＮＡＮＡiWotuBZ0Fx
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（圖2）左圖為Panax notoginseng（三七）；550Please respect copyright.ＰＥＮＡＮＡ8NFbhEfwAJ
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中圖為Sedum aizoon（土三七）；550Please respect copyright.ＰＥＮＡＮＡYyJbMzx30a
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而右圖則為Gynura japonica，頻繁被誤當成土三七的藥材。550Please respect copyright.ＰＥＮＡＮＡbeMJSqUGvm
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（圖3）不幸的是，這款誤當成土三七的藥材內含名為pyrrolizidine alkaloids (PAs)的化學物；550Please respect copyright.ＰＥＮＡＮＡ7Ukzc220rd
真正的三七及土三七並不含PAs。550Please respect copyright.ＰＥＮＡＮＡgEhBZOz3eP
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這些PA化學物進入人體後，會形成DHPA及DHP化學物。550Please respect copyright.ＰＥＮＡＮＡ1FRiYtUe0b
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而DHPA及DHP化學物會與肝臟內各種蛋白質結合，導致肝臟無法運作正常。550Please respect copyright.ＰＥＮＡＮＡRpQIacieAL
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根據資料統計(Ref1)，誤當Gynura japonica作為土三七下藥，構成了中國在2017年約10-30%因攝取藥物導致肝臟收損的個案。550Please respect copyright.ＰＥＮＡＮＡ4b6n93kIWF
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這亦表示，若有經驗不足的中藥醫師或商人胡亂購買藥材的話，將會無意之間害了別人。550Please respect copyright.ＰＥＮＡＮＡ7NTkwzwttn
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能否有系統分配及管理中藥藥材的類別，將會是現今中醫所需面對的問題。550Please respect copyright.ＰＥＮＡＮＡbYe639uOv0
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有興趣繼續觀看用西醫角度觀看中藥的話，請給予正評及留言，反應熱烈的話將會寫新一集。550Please respect copyright.ＰＥＮＡＮＡ22CPw3YBxo
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。550Please respect copyright.ＰＥＮＡＮＡhPeFFJ3rLF
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc550Please respect copyright.ＰＥＮＡＮＡbPTlgYrbNL
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。550Please respect copyright.ＰＥＮＡＮＡHynOBdFju5
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Link:550Please respect copyright.ＰＥＮＡＮＡnlBYmL4Uhq
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio550Please respect copyright.ＰＥＮＡＮＡO3ol7ziv5o
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。550Please respect copyright.ＰＥＮＡＮＡjmfWlVGcbx
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Ref1:https://www.nature.com/articles/s41401-020-00553-9550Please respect copyright.ＰＥＮＡＮＡCViP5bH3a8