科普專欄–薯不揀單 - 深入淺出–基因變異是否癌細胞形成的決定因素?

隨著細胞的基因變異一直累積，正常細胞形成癌細胞的機會亦會相應提升。587Please respect copyright.ＰＥＮＡＮＡAt6UEjBWuN
587Please respect copyright.ＰＥＮＡＮＡxrQPEWzeBQ
但細胞是否只需要基因變異這一個誘因便能夠轉化為癌細胞呢？587Please respect copyright.ＰＥＮＡＮＡ8Vs2564RzA
587Please respect copyright.ＰＥＮＡＮＡXhxIhHjZCf
這一方面還有一定程度的斟酌空間。587Please respect copyright.ＰＥＮＡＮＡCSNn6g9jMj
587Please respect copyright.ＰＥＮＡＮＡOFLzsPH15W
587Please respect copyright.ＰＥＮＡＮＡ9vn9s4WXod
舉例來說，NOTCH1基因變異被認定為是推進食道細胞轉化成為癌細胞的其中一個原因。587Please respect copyright.ＰＥＮＡＮＡIJ9IMOTLDZ
587Please respect copyright.ＰＥＮＡＮＡsIXUMl2Scb
但在長者的健康食道細胞裡頭，約有30-80%的細胞均擁有NOTCH1基因變異，而他們身體並沒有出現及發生食道癌。587Please respect copyright.ＰＥＮＡＮＡ9VvPVPk4SE
587Please respect copyright.ＰＥＮＡＮＡ5858z42ikT
587Please respect copyright.ＰＥＮＡＮＡob164BvMlO
（圖2）而在老鼠實驗方面，單憑服用DMBA (引致Hras基因變異)或Croton oil(引致發炎效用，不會促進基因變異)的話，並不會引起癌細胞的出現。587Please respect copyright.ＰＥＮＡＮＡAzQLKrFO49
587Please respect copyright.ＰＥＮＡＮＡ9syg1HQMIT
唯獨兩者以先後的方式給予老鼠的話，癌細胞才會有所形成。587Please respect copyright.ＰＥＮＡＮＡV5jMdSaIxz
587Please respect copyright.ＰＥＮＡＮＡX9WtadbqY7
587Please respect copyright.ＰＥＮＡＮＡJL9yPI5Xwj
587Please respect copyright.ＰＥＮＡＮＡ1RoL4tPMo4
這不禁讓科學家開始思考一道問題，是否基因變異再加上某種特定條件，就可以促進癌細胞形成呢？587Please respect copyright.ＰＥＮＡＮＡ0TkzI5fMP9
587Please respect copyright.ＰＥＮＡＮＡDyO144JFey
（圖3）為解答這個問題，英國開始了名為Mutographs的計劃，587Please respect copyright.ＰＥＮＡＮＡck7rG63ZGw
587Please respect copyright.ＰＥＮＡＮＡwcn48TKiJn
587Please respect copyright.ＰＥＮＡＮＡj4zQbcgTgG
集5大洲超過5000個病人的癌細胞基因圖譜(主要集中在食道、大腸、腎臟及胰臟癌)，587Please respect copyright.ＰＥＮＡＮＡh7NfxSXblh
587Please respect copyright.ＰＥＮＡＮＡBgyWLUATI7
同時比對病人的日常習慣(食用習慣、酒精飲用、熱飲喜好等等)，587Please respect copyright.ＰＥＮＡＮＡpIeetk4cbc
587Please respect copyright.ＰＥＮＡＮＡAD3oQrkgMJ
其中一個目標就是想找出哪一種特殊條件配上某一個基因變異會特別容易促進癌細胞的形成。587Please respect copyright.ＰＥＮＡＮＡCHbjGfWjjO
587Please respect copyright.ＰＥＮＡＮＡnEEREt0CMq
若然能得出確切的結果並附上內裡的細胞機制支持的話，這將會為預防癌症形成的領域作出重大的貢獻。587Please respect copyright.ＰＥＮＡＮＡgDZKliO93M
587Please respect copyright.ＰＥＮＡＮＡOqeC5z4eCm
以上的資料均取自Ref1。587Please respect copyright.ＰＥＮＡＮＡTRWcyuPczI
587Please respect copyright.ＰＥＮＡＮＡFWIVhlbt0l
587Please respect copyright.ＰＥＮＡＮＡ3AWbi5lOeH
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。587Please respect copyright.ＰＥＮＡＮＡ83QLSWzVOJ
587Please respect copyright.ＰＥＮＡＮＡbrUE6OjiIv
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc587Please respect copyright.ＰＥＮＡＮＡfBHh1rnwGh
587Please respect copyright.ＰＥＮＡＮＡSnIFBjrZTT
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。587Please respect copyright.ＰＥＮＡＮＡYbRoZINzgq
587Please respect copyright.ＰＥＮＡＮＡLaMnyoggkE
Link:587Please respect copyright.ＰＥＮＡＮＡCiqOoowOP1
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio587Please respect copyright.ＰＥＮＡＮＡUmUuXVl5cJ
587Please respect copyright.ＰＥＮＡＮＡdxf2gb3Qyb
587Please respect copyright.ＰＥＮＡＮＡJkrPbNPF9o
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。587Please respect copyright.ＰＥＮＡＮＡ2JIkiZBaNx
587Please respect copyright.ＰＥＮＡＮＡHiVAybgudL
https://www.instagram.com/potatopigtongue/587Please respect copyright.ＰＥＮＡＮＡ2wMRBGicI6
587Please respect copyright.ＰＥＮＡＮＡyjYUe4R16X
Ref1:https://www.nature.com/articles/s41588-020-00727-5

ns216.73.216.206da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章