科普專欄–薯不揀單 - 深入淺出–基因變異是否癌細胞形成的決定因素?

隨著細胞的基因變異一直累積，正常細胞形成癌細胞的機會亦會相應提升。523Please respect copyright.ＰＥＮＡＮＡ3IDSmano3r
523Please respect copyright.ＰＥＮＡＮＡl8c7kyEcd7
但細胞是否只需要基因變異這一個誘因便能夠轉化為癌細胞呢？523Please respect copyright.ＰＥＮＡＮＡmMEpKkeMbf
523Please respect copyright.ＰＥＮＡＮＡijYt8cndLs
這一方面還有一定程度的斟酌空間。523Please respect copyright.ＰＥＮＡＮＡVK6vupJYhO
523Please respect copyright.ＰＥＮＡＮＡswItjyGogy
523Please respect copyright.ＰＥＮＡＮＡ4cHvk3R56O
舉例來說，NOTCH1基因變異被認定為是推進食道細胞轉化成為癌細胞的其中一個原因。523Please respect copyright.ＰＥＮＡＮＡpIVTGnruQV
523Please respect copyright.ＰＥＮＡＮＡjVyzW8o0si
但在長者的健康食道細胞裡頭，約有30-80%的細胞均擁有NOTCH1基因變異，而他們身體並沒有出現及發生食道癌。523Please respect copyright.ＰＥＮＡＮＡViQfZaptYz
523Please respect copyright.ＰＥＮＡＮＡHsjggUBx4H
523Please respect copyright.ＰＥＮＡＮＡ2yiuviWbrO
（圖2）而在老鼠實驗方面，單憑服用DMBA (引致Hras基因變異)或Croton oil(引致發炎效用，不會促進基因變異)的話，並不會引起癌細胞的出現。523Please respect copyright.ＰＥＮＡＮＡeNJqfQG0gR
523Please respect copyright.ＰＥＮＡＮＡGXZ2IR086J
唯獨兩者以先後的方式給予老鼠的話，癌細胞才會有所形成。523Please respect copyright.ＰＥＮＡＮＡxj4TEI6Atf
523Please respect copyright.ＰＥＮＡＮＡkIRCe5soMc
523Please respect copyright.ＰＥＮＡＮＡNA1XLMORzR
523Please respect copyright.ＰＥＮＡＮＡJgieD4iWz7
這不禁讓科學家開始思考一道問題，是否基因變異再加上某種特定條件，就可以促進癌細胞形成呢？523Please respect copyright.ＰＥＮＡＮＡ7atoFDQvan
523Please respect copyright.ＰＥＮＡＮＡFR8YzD8lGd
（圖3）為解答這個問題，英國開始了名為Mutographs的計劃，523Please respect copyright.ＰＥＮＡＮＡPKOnlNiLln
523Please respect copyright.ＰＥＮＡＮＡldi5FdmUVM
523Please respect copyright.ＰＥＮＡＮＡtt2eGy18HT
集5大洲超過5000個病人的癌細胞基因圖譜(主要集中在食道、大腸、腎臟及胰臟癌)，523Please respect copyright.ＰＥＮＡＮＡMKA5ubZR31
523Please respect copyright.ＰＥＮＡＮＡkFMvcesHQ3
同時比對病人的日常習慣(食用習慣、酒精飲用、熱飲喜好等等)，523Please respect copyright.ＰＥＮＡＮＡpYaBLJwPc3
523Please respect copyright.ＰＥＮＡＮＡShukynW5qk
其中一個目標就是想找出哪一種特殊條件配上某一個基因變異會特別容易促進癌細胞的形成。523Please respect copyright.ＰＥＮＡＮＡanczJJHi3g
523Please respect copyright.ＰＥＮＡＮＡg2ddDFB70J
若然能得出確切的結果並附上內裡的細胞機制支持的話，這將會為預防癌症形成的領域作出重大的貢獻。523Please respect copyright.ＰＥＮＡＮＡpoRgj2N75A
523Please respect copyright.ＰＥＮＡＮＡkZShgyyHCk
以上的資料均取自Ref1。523Please respect copyright.ＰＥＮＡＮＡ5nHkPJfUlc
523Please respect copyright.ＰＥＮＡＮＡjkEg74daaM
523Please respect copyright.ＰＥＮＡＮＡoi9Kup4tC3
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。523Please respect copyright.ＰＥＮＡＮＡggOrJn2LQq
523Please respect copyright.ＰＥＮＡＮＡ9WZnDSRItf
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc523Please respect copyright.ＰＥＮＡＮＡMSeoDmnDyZ
523Please respect copyright.ＰＥＮＡＮＡjIszFgN8Ko
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。523Please respect copyright.ＰＥＮＡＮＡx5U83KIwJg
523Please respect copyright.ＰＥＮＡＮＡLMnZcNQuJn
Link:523Please respect copyright.ＰＥＮＡＮＡy3XcZjhKdh
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio523Please respect copyright.ＰＥＮＡＮＡTeXrbztKdR
523Please respect copyright.ＰＥＮＡＮＡcvd7mLbYoK
523Please respect copyright.ＰＥＮＡＮＡNhg5vG5NJJ
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。523Please respect copyright.ＰＥＮＡＮＡBzZKkWwdN6
523Please respect copyright.ＰＥＮＡＮＡ7I73ckQ3B6
https://www.instagram.com/potatopigtongue/523Please respect copyright.ＰＥＮＡＮＡIcPDy39mNw
523Please respect copyright.ＰＥＮＡＮＡCpMDvNtZCE
Ref1:https://www.nature.com/articles/s41588-020-00727-5

ns18.223.122.53da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章